Karen Tweedy-Holmes is a horse-obsessed free-lance photographer based in New York City whose work is largely devoted to portraiture of human beings and wild and domestic animals and to depicting the landscape and animals of the desert Southwest. Her images of the male nude were exhibited extensively to critical acclaim in the 1970s and are among the first art photographs of this subject by an American woman. Tweedy-Holmes was awarded grants from the Mindlin Foundation to photograph the threatened Bisti Badlands of New Mexico (1999) and the Grand Staircase/ Escalante National Monument in Utah (2000). Her work has been published in many periodicals and newspapers including Popular Photography, Infinity, Art in America, Time, National Geographic, Geo, Animals, The Boston Globe, The New York Times, Jazz Times, Dance, Newsweek, B&W Magazine, Nature, and The Sun.
It has been exhibited widely and is represented in numerous museum collections, including those of the International Center of Photography and the Cooper-Hewitt Museum, New York; the Museum of New Mexico, Santa Fe; the Akron Museum of Art, Akron, Ohio; and The National Museum of Women in the Arts, Washington, D.C.

Tweedy-Holmes's first book, Thought to Exist in the Wild (2007), a severely critical consideration of zoos, with text by the environmental activist Derrick Jensen, won the 2008 Grand Prize of the Eric Hoffer Book Award and the Silver Medal of the 2008 Independent Publisher Book Awards in the Animal category.

Her second book,
Horse Sanctuary, documenting and celebrating the work of 13 equine sanctuaries throughout the United States, with text by Allison Milionis and foreword by Temple Grandin was published in March 2013 by Universe, a division of Rizzoli.

Photograph by Karen Parker, 2011